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It is also called San Biagio della Pagnotta (St Blaise of the Loaf), from the small blessed loaves that are distributed to the people and especially the poor on the feast day of the titular saint (3 February).

In medieval documents, the church takes on various names (San Biagio gastru secuta, gatta secuta, cantu securo, clatro secura, cantu secuta, monte secuto), all referable to the expression de cantu secuta, in reference to caput seccutae: in the 13th century, the people called seccuta the bank of the Tiber where Via Giulia now runs, and where the river left a large deposit of sand and silt.

The church is mentioned several times in medieval catalogues; its origin predates the 10th century, but it is first mentioned in an epigraph inside the church, dated 1072, in which it is recorded that Abbot Dominic, of the adjoining monastery (now converted into a hotel), rebuilt the church under Pope Alexander II. In 1836, Pope Gregory XVI entrusted the church to the Armenians, who made it their national church.

Today's façade of the church is the work of Giovanni Antonio Perfetti, who is also responsible for the 18th-century renovation of the church; above is a fresco depicting St Blaise performing a miracle.

The interior, renovated by Filippo Navone in the first part of the 19th century, houses the relics of St Biagio's throat, a fresco of Angels in the act of adoring the Sacrament by Pietro da Cortona, and an image of Our Lady of Graces (1671). On the left, an altar with an Icon of Maria S.S. di Ripalta, patron saint of Cerignola and Ascoli Satriano. It is a copy of the original from 1172, placed in the Diocesan Sanctuary in the Cerignola countryside for the devotion of the people of Cerignola living in Rome.